To examine the effect of zinc in the removal of accumulated arsenic from different tissues Oiver, kidneys, spleen and lungs), rats were initially allowed to drink high concentration (400 ~gIday) of arsenic for two months followed by a period of cessation (one month). Administration of zinc (2 mglkg/day) during the third month in arsenic-treated and non-treated groups were compared. In arsenic-treated rats, the mean(::!:SD) amounts oftotal arsenic in liver, kidneys, spleen and lungs were 12.3:tO.7, 20.5:!:1.0, 31.4:!:1.0 and 25.6:!:1.1 ~g of tissues respectively.