Thyroid hormone profile in beta-thalassemia major children

Thalassemia is the most common genetic disorder worldwide1 . The striking increase in survival of these patients over the past decade has focused attention on abnormal endocrine function, now the most prevalent iron-induced complication in older patients2 . Trans-fusion related iron overload is the primary therapeutic complication in thalassemia major. Hemosiderosis of various endocrine glands including the thyroid gland has been documented histologically in chronically transfused patients including thalassemics.


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