The present study aimed to investigate the households’ impoverishment due to the healthcare costs in Shiraz in 2012. In this household’s survey, 800 households were studied in Shiraz. The study sample was selected using stratified and cluster sampling in the urban and rural areas, respectively. The information was collected using the household section of the World Health Survey questionnaire. In order to determine impoverishment due to health spending, at first, the households’ food-based poverty line (subsistence expenditure) was measured. Then, households’ health expenditure was subtracted from their total expenditure and if the obtained value was lower than the households’ food-based poverty line, the households was considered to be impoverished due to health expenditures.