Cytomegalovirus infection is endemic in most countries. It is a DNA virus and after its primary occurrence becomes latent and periodic reactivation with intermittent viral shedding may continue throughout life. The virus shedding occurs in different components of the body fluid as saliva, urine, feces, blood, semen, cervical secretion and breast milk. The virus can cross the placenta and congenital infection of the fetus might occur in any time of gestational period.