Plasma total ascorbate status measured by 2.4 dinitrophenyl hydrazine method showed that diabetics (N =1(0) had significantly lower plasma total ascorbate compared with 45 age and sex matched non-diabetic controls; 0.34:tO.16mg/dl vs O.68:t.06 mg/dl, P<O.OOI)regardless of presence or absence of retinopathy and irrespective of mode of treatment.The finding unique to thisstudy was that plasma total ascorbate statusin diabetics with retinopathy (O.19:tO.07mg/dl) was significantly lower than that of uncomplicated diabetics (0.49:tO.06mg/dl; P<O.OOI)…