Role of a Large Plasmid in Mediation of Multiple Drug Resistance in Salmonella Typhi and Paratyphi A in Bangladesh

From 405 patients of suspected typhoid fever, 94 Salmonella typhi and 17 Salmonella paratyphi A,were isolated from blood and lor stool at the Institute of Postgraduate Medicine and Research, Dhaka during March 1992 to February 1993. Forty seven percent of the isolates were resistant to multiple drugs which included amoxicillin, ampicillin, chloramphenicol and co-trimoxazole. Alarge plasmid of 140MDa was isolated from 73% of multidrug resistant (MDR)strains. However, no plasmid was isolated from any of the strains sensitive to…

 

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