Several factors involved in the regulation of serum protein and cholesterol levels of humans as well as rodents. Cold exposure is the major sympathetic and environmental stimuli regulating metabolic functions1 . After prolonged exposure of rats to cold, a sustained increase in systolic blood pressure occurs, giving rise to a cold-induced model of hypertension2 . Activation of the sympathetic nervous system is thought to contribute to the development of hypertension in cold-exposed rats3 . Sympathetic input to the