Infantile hemangiomas are the most common vascular tumor of infancy and childhood. Sometimes these lesions interfere with normal function and produce serious disfigurement that is unlikely to resolve on its own and then treatment is required. Dramatic improvement of complicated haemangioma by propranolol has recently been reported, but to date, details for initiating therapy, monitoring and potential risks in relation to corticosteroids were not compared in a large scale. This study was designed to observe the effectiveness of oral propranolol compared to oral corticosteroid treating clinically important groups of infantile hemangiomas that require aggressive treatment.