Histmorphological Study of Indomethacin Induced Gastrointestinal Lesions in Rat

This study was undertaken in Long Evans rat to investigate the effect of a singletherapeutic as well as toxic dose of indomethacin on the gastrointestinal mucosa. The effect was studied morphologically six hours after oral administration of the drug. The affected tissue was then examined histologically. The histomorphological evaluation revealed that the drug has induced acute hemorrhagic erosive gastritis in the fasted animals (6 mglKg body weight) where as in normally fed (10 mg/kg body weight) rats…

 

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