Glyceryl trinitrate: The management of chronic anal fissure in patients who are unfit for surgery

We read with great interest the article by Siddique et al.1 whose work shows that lateral internal sphincterotomy is the treatment of choice in chronic anal fissure when compared with 0.2 percent glyceryl trinitrate. We would like to further discuss this article by introducing a major route through which 0.2 percent glyceryl trinitrate could use in patients who are unfit for surgery.


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