Gastrointestinal stromal tumor of the rectum : An analysis of six cases

Gastrointestinal stromal tumors (GISTs) are a type of neoplasm asrising from the precursor cell of interstitial cell of Cajal in the myenteric plexus of gastrointestinal tract1 . At present GIST may be defined as morphologically spindle cell, epitheloid cell or occasionally pleomorphic mesenchymal cell tumor that usually arise from the gastrointestinal tract, usually express the KIT protein and harbor mutation of a gene that encodes for a type III receptor tyrosine kinase either KIT or PDGFRA in upto 90% of cases2.


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