Gamma interferon (IFN-γ) plays an important role in the immune response to live measles virus vaccination. To study the immune response to measles vaccination, IFN-γ level was estimated in 30children. Of these, 24 children vaccinated with a single dose of measles vaccine at nine months of age and 06 children vaccinated with a second dose during the Measles Catch-up Immunization campaign. Measles vaccine strain was cultured in Vero cell line and the Tissue Culture Infective Dose (TCID)50 was used as standard live virus.