Evaluation of Co-Agglutination (COA), Counter Immunoelec-trophoresis (CIE), Culture and Direct Microscopic (Dm) Examination of Cerebrospinal Fluid (CSF) for detection of Meningitis caused by common bacterial pathogens

Cerebrospinal fluid from 260 children clinically diagnosed as meningitis were examined by Om, culture, COA and CIE test. Om revealed the presence of bacteria in 41(15.8%) whereas culture showed growth of organism in 52(20%) cases. COA and CIE test were done for the detection of antigen of H. influenzae S. pneumoniae and N. meningitidis. Among the 3 methods viz. culture, COA and CIE test which were used for the detection of the above three organisms COA detected the maximum numbers(23.5%). COA test could detectantigen in both culture positive and culture negative CSF samples. COA test detected 100% of pneumococcal, 88.5% of H. influenzae and 66…

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