Effects of Tranquillising, Antidepressant and Central Nervous System Stimulant Drugs on the y-Aminobutyric Acid (GABA) Level of Rat Brain

A significant correlation has been suggested between the y-aminobutyric acid (GABA) content of the brain and the electroshock seizure threshold (Woodbury and Esplin, 1959). Blockade of GABA activity or reduced level of GABA in the brain has been suggested to be generally involved in causing seizures (Maynert and Kaji, 1962). The seizure induced by thiosemicarbazide (Sze and Lovell, 1970) and insulin hypoglycaemia…

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