This study was conducted with a view to find out the effect of suppressive therapy with thyroxine on the size 9f solitary thyroid nodules. Sixty-one patients attending the Thyroid Clinic and Institute ofN~clear Medicine, IPGMR, Dhaka between March 1994 and December 1994 were randomly allocated to either thyroxine or placebo groups. The treatment was continued for six months. Thirty subjects from the thyroxine and 25 from the placebo groups completed the trial. Data on serum TSH at the end of the trial…