Double balloon enteroscopy (DBE) is a newly developed endoscopic modality for diagnosis and treatment of small bowel disorders. The aim of this study was to evaluate the diagnostic and therapeutic impact of DBE in patient with suspected small bowel disease. This was a prospective study. Sixty one double balloon enteroscopy procedures (30 antegrade 31 retrograde) were done in thirty six patients(20M/16F, mean age 40±12.5 range 16-65 years ) at gastroenterology department, Sir Salimullah Medical College, Dhaka between October 2011 and September 2012. Indications for DBE included chronic abdominal pain 14(38.9%), obscure GI bleeding 11(30.56%), Small bowel obstruction 05(13.89%), and chronic diarrhea 06(16.67%). The morphologic findings were ulcerations 13(36.11%), growth 03(8.33%), vascular ectasia 03(8.33%) and polyp 01(2.78%).