Double contrast barium meal examination was done in 241 cases referred from various in-patient and out-patient departments of Sir Salimullah Medical Mitford Hospital, Dhaka, Bangladesh. Out of 241, 150 cases were xamined by 10cally prepared negative contrast agent of whieh upper gestrontestinal endoscopy was done in 52 cases. This was done for comparison )f validity between endoscopy and double contrast barium meal X.ray. Loca1l1y )repared agent was found to be effective i I comparison to foreign made noga- :ive contrast agents. Radiological error ratio in ulcer detection was 5.77%, Nhen proportional test ‘d’ was applied to fi…