Biochemical and Immunological Markers for the Early Diagnosis of Neonatal Septicaemia

Background: Neonatal sepsis is a life-threatening condition with high mortality and morbidity throughout the world.

Objective: This study evaluated the diagnostic role of serum procalcitonin (PCT), interleukin-6 (IL-6), tumor necrosis factor- (TNF-) and C-reactive protein (CRP) in the early diagnosis of neonatal sepsis.

Methods: This cross-sectional study was conducted among neonates admitted to the special baby care unit
(SCABU) of BIRDEM General Hospital, Dhaka, from November 2018 to April 2019. According to selection criteria, 90 clinically suspected cases of neonatal sepsis were selected and categorised into confirmed, probable, and no sepsis groups based on CRP, white cell count, platelet count, and blood culture results. Serum PCT, IL6, and tumor necrosis factor (TNF-) were estimated in all cases by standard laboratory methods.


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